Rati Sharma
Computational and Experimental Biophysics
Assistant Professor
Phone:
+91 755 269 1357
rati@iiserb.ac.in
Rati Sharma
Computational and Experimental Biophysics
Assistant Professor
Phone:
+91 755 269 1357
rati@iiserb.ac.in
Rati Sharma
Computational and Experimental Biophysics
Assistant Professor
Phone:
+91 755 269 1357
rati@iiserb.ac.in
The computational and experimental biophysics lab will combine theoretical techniques of non-equilibrium statistical mechanics to make models and predictions along with stress based experiments (such as heat shock, pathogen infection, osmotic stress) performed on the model organism C. elegans (1mm long nematode found commonly in the soil) to answer fundamental questions in science. The lab will be focused on three specific areas. They are:
- Noise in cellular kinetic pathways: Computer simulations and mathematical models based on statistical mechanics will be used to understand how they affect cellular dynamics.
- Stress-response dynamics using C. elegans as a model organism and their connection to survival and behavior. This will incorporate the use of microfluidics and imaging through a microscope along with RNA biology.
- Probing large interaction networks through machine learning. This will involve using and curating large biological public datasets and making predictions.
Rati Sharma
Assistant Professor
Computational and Experimental Biophysics
| # | Authors | Title | Journals | Year |
|---|---|---|---|---|
| 1 | Rati Sharma Debasish Saha |
Work distribution of a colloid in an elongational flow field and under Ornstein-Uhlenbeck noise. | Physical Review E | 2024 |
| 2 | Binil Shyam TV Rati Sharma |
mRNA translation from a unidirectional traffic perspective. | Physica A | 2024 |
| 3 | Abhijit Patra Rati Sharma Abhilasha Batra Subhankar Kundu Subhadeep Das |
Unveiling Autophagy and Aging through Time-Resolved Imaging of Lysosomal Polarity with a Delayed fluorescent emitter | Chemical Science | 2024 |
| 4 | Anand Anilkumar Abhilasha Batra Santanu Talukder Rati Sharma |
Microfluidics based bioimaging with cost-efficient fabrication of multi-level micrometer-sized trenches | Biomicrofluidics | 2023 |
| 5 | Khursheed Ahmad Khan Shoubhik Chandan Banerjee Rati Sharma |
Deep-worm-tracker: Deep learning methods for accurate detection and tracking for behavioral studies in C. elegans | Applied Animal Behaviour Science | 2023 |
| 6 | Rati Sharma |
Extrinsic noise effects on ribosomal traffic during the translation process | Journal of Statistical Mechanics: Theory and Experiment (JSTAT) | 2022 |
| 7 | Rati Sharma Ayush Ranawade Erel Levine |
Lessons Learned from Two Decades of Modeling the Heat-Shock Response | Biomolecules | 2022 |
| 8 | Shoubhik Chandan Banerjee Abhilasha Batra Rati Sharma |
Persistent Correlation in Cellular Noise Determines Longevity of Viral Infections | The Journal of Physical Chemistry Letters | 2022 |
| 9 | Abhilasha Batra Rati Sharma |
A near analytic solution of a stochastic immune response model considering variability in virus and T cell dynamics. | The Journal of Chemical Physics | 2021 |
| 10 | Rati Sharma Sushmita Pal |
Transcription factors and chaperone proteins play a role in launching a faster response to heat stress and aggregation. | Computational Biology and Chemistry | 2021 |
