Profile || Department of Chemistry

Group Page

Ishu Saraogi

Organic Chemistry and Chemical Biology
Associate Professor
Phone: +91 755 269 1309, 669 1309
ishu@iiserb.ac.in

Group Page

Ishu Saraogi

Organic Chemistry and Chemical Biology
Associate Professor
Phone: +91 755 269 1309, 669 1309
ishu@iiserb.ac.in

Assistant Professor,Chemistry, Indian Institute of Science Education and Research, Bhopal, India.

Post-Doctoral California Institute of Technology, USA. Advisor: Shu-ou Shan

Ph. D. (2008),Yale University, USA. Advisor: Andrew D. Hamilton

M.S. (2003),Indian Institute of Science, Bangalore. Advisor: T. N. Guru Row

B.Sc.(Honors) (2000),University of Calcutta.

Group Page

Ishu Saraogi

Organic Chemistry and Chemical Biology
Associate Professor
Phone: +91 755 269 1309, 669 1309
ishu@iiserb.ac.in

Using a combination of organic chemistry and molecular biology techniques, our research will be focused in the following areas:

Exploiting protein biosynthesis machinery for non-natural applications using stop codon reassignment.

Biophysical and biochemical assays for studying protein-protein and protein-ligand binding with a strong emphasis on fluorescence.

High-throughput and rational design methods to inhibit protein-protein interactions, primarily aimed at identifying novel antibacterial targets.

Ishu Saraogi

Associate Professor
Organic Chemistry and Chemical Biology

#	Authors	Title	Journals	Year
1	Sudipta Ghosh Khushboo Goel Snehlata Saini Ishu Saraogi Anirban Das	Effects of PNA Sequence and Target Site Selection on Function of a 4.5S Non-coding RNA	ChemBioChem	2024
2	Anirban Das Pooja Sah Ishu Saraogi	Dual role of a fluorescent small molecule as a sensor and inhibitor of protein fibrillation	Chemistry an Asian Journal	2023
3	Chitra Shanbhag Ishu Saraogi	Bacterial GTPases as druggable targets to tackle antimicrobial resistance	Bioorganic and Medicinal Chemistry Letters	2023
4	Snehlata Saini Chitra Shanbhag Ishu Saraogi	Chemical approaches to tackle the silent pandemic of antibiotic resistance	AsiaChem	2023
5	Upasana Potteth Vaibhav Karekar Tulsi Upadhyay Ishu Saraogi	A buried interchain aromatic cluster in Escherichia coli GrpE governs in vivo thermosensing activity	Proteins	2023
6	Snehlata Saini Tulsi Upadhyay Upasana S Potteth Ishu Saraogi	Novel Antibacterial Targets in Protein Biogenesis Pathways	ChemBioChem	2022
7	Anirban Das Mosami Sah Ishu Saraogi	Molecular aspects of insulin aggregation and its inhibition using small molecules	ACS Bio & Med Chem Au	2022
8	Purnima Mala Ishu Saraogi	Increased H-bonding enhances codon-anticodon interaction at in-frame UAG stop codon during non-natural amino acid mutagenesis	ACS Chemical Biology	2022
9	Ishu Saraogi Subhendu S Bag Jiantao Guo	Expansion of the Genetic Code: Unnatural Amino Acids and their Applications	Frontiers in Chemistry	2022
10	Anirban Das Yogesh Gangarde Ranit Pariary Anirban Bhunia Ishu Saraogi	An amphiphilic small molecule drives insulin aggregation inhibition and amyloid disintegration	International Journal of Biological Macromolecules	2022
11	Vaibhav Karekar Upasana Potteth Tulsi Upadhyay Ishu Saraogi	A stutter in the coiled-coil domain of E.coli co-chaperone GrpE connects structure with function	Biochemistry	2021
12	Jainu Ajit Anirban Das Yogesh Gangarde Ishu Saraogi	Synthesis and Evaluation of Arylamides with Hydrophobic Side Chains for Insulin Aggregation Inhibition	ChemPlusChem	2021
13	Anirban Das Tanoy Datta Laxmikant Gadhe Apurba Lal Koner Ishu Saraogi	Biocompatible fluorescent probe for selective detection of amyloid fibrils	Analytical Chemistry	2020
14	Anirban Das Yogesh Gangarde Viniti Tomar Omkar Shinde Tulsi Upadhyay Sarfaraz Alam Sudipta Ghosh Varun Chaudhary Ishu Saraogi	A small molecule inhibitor prevents insulin fibrillogenesis and preserves activity	Molecular Pharmaceutics	2020
15	Yogesh Gangarde Sajeev T K Nihar Panigrahi Ram K Mishra Ishu Saraogi	Amphiphilic small molecule assemblies to enhance the solubility and stability of hydrophobic drugs	ACS Omega	2020
16	Bapurao Bhoge Purnima Mala Jo S Kurian Varadharajan Srinivasan Ishu Saraogi	Selective functionalization at N2-position of guanine in oligonucleotides via reductive amination	Chemical Communications	2020
17	Vaibhav Karekar Bhoge Bapurao Saraogi Ishu	An expeditious synthetic route to proteomimetic foldamers	New Journal of Chemistry	2019
18	Ishu Saraogi Snehlata Saini Sudipta Ghosh	Peptide nucleic acid mediated inhibition of the bacterial signal recognition particle	Chemical Communications	2018
19	Ishu Saraogi David Akopian Shu-ou Shan	Real time fluorescence reveals the recognition, commitment, and unloading of cargo during co-translational protein targeting	Jl. Of Cell Biology	2014
20	Ishu Saraogi Shu-ou Shan	Co-translational protein targeting to the bacterial membrane	BBA-Molecular Cell Research	2014