Dr. Ishu Saraogi

Organic Chemistry and Chemical Biology

  • Designation : Assistant Professor
  • Phone : +91 755 269 1309, 669 1309
  • Email : ishu@iiserb.ac.in
  • Fax : +91 755 669 2392
Academic Details

Assistant Professor,Chemistry, Indian Institute of Science Education and Research, Bhopal, India.

Post-Doctoral California Institute of Technology, USA. Advisor: Shu-ou Shan

Ph. D. (2008),Yale University, USA. Advisor: Andrew D. Hamilton

M.S. (2003),Indian Institute of Science, Bangalore. Advisor: T. N. Guru Row

B.Sc.(Honors) (2000),University of Calcutta.

Profile Details

    Using a combination of organic chemistry and molecular biology techniques, our research will be focused in the following areas:

    Exploiting protein biosynthesis machinery for non-natural applications using stop codon reassignment.

    Biophysical and biochemical assays for studying protein-protein and protein-ligand binding with a strong emphasis on fluorescence.

    High-throughput and rational design methods to inhibit protein-protein interactions, primarily aimed at identifying novel antibacterial targets.

    • Saraogi, I.; Vijay, V.G.; Das, S.; Sekar, K.; Row, T.N.G; C-halogen.... interactions in proteins: a database study; Cryst. Engg. 2003, 6(2), 69

    • Becerril, J; Rodriguez, J.M.; Saraogi, I.; Hamilton, A.D.; .Foldamer-based Molecular Recognition. in Foldamers: Structure, Properties and Applications. Hecht, S. and Huc, I. Eds.; Wiley-VCH, Weinheim, 2007

    • Saraogi, I.; Hamilton, A.D.; ..-helix mimetics as inhibitors of protein-protein interactions., Biochem. Soc. Trans. 2008, 36, 1414

    • Saraogi, I.; Incarvito, C.D.; Hamilton, A.D.; .Controlling curvature in a family of oligoamide .-helix mimetics., Angew. Chem. Int. Ed. 2008, 47, 9691

    • Hebda, J.A.; Saraogi, I.; Magzoub, M.; Hamilton, A.D.; Miranker, A.D.; .A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chem. Biol. 2009, 16, 943

    • Saraogi, I.; Hamilton, A.D.; .Recent advances in the development of aryl-based foldamers., Chem. Soc. Rev. 2009, 38, 1726

    • Saraogi, I.; Hebda, J.A.; Becerril, J.; Estroff, L.A.; Miranker, A.D.; Hamilton, A.D.; .Synthetic .-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angew. Chem. Int. Ed. 2010, 49, 736

    • Saraogi, I.; Shan, S.; .Molecular mechanism of co-translational protein targeting by the Signal Recognition Particle. Traffic 2011, 12, 535