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Ishu Saraogi

Organic Chemistry and Chemical Biology
Associate Professor
Phone: +91 755 269 1309, 669 1309
ishu@iiserb.ac.in

Assistant Professor,Chemistry, Indian Institute of Science Education and Research, Bhopal, India.

Post-Doctoral California Institute of Technology, USA. Advisor: Shu-ou Shan

Ph. D. (2008),Yale University, USA. Advisor: Andrew D. Hamilton

M.S. (2003),Indian Institute of Science, Bangalore. Advisor: T. N. Guru Row

B.Sc.(Honors) (2000),University of Calcutta.

Using a combination of organic chemistry and molecular biology techniques, our research will be focused in the following areas:

Exploiting protein biosynthesis machinery for non-natural applications using stop codon reassignment.

Biophysical and biochemical assays for studying protein-protein and protein-ligand binding with a strong emphasis on fluorescence.

High-throughput and rational design methods to inhibit protein-protein interactions, primarily aimed at identifying novel antibacterial targets.

#	Authors	Title	Journals	Year
1	Snehlata Saini Tulsi Upadhyay Upasana S Potteth Ishu Saraogi	Novel Antibacterial Targets in Protein Biogenesis Pathways	ChemBioChem	2022
2	Anirban Das Mosami Sah Ishu Saraogi	Molecular aspects of insulin aggregation and its inhibition using small molecules	ACS Bio & Med Chem Au	2022
3	Purnima Mala Ishu Saraogi	Increased H-bonding enhances codon-anticodon interaction at in-frame UAG stop codon during non-natural amino acid mutagenesis	ACS Chemical Biology	2022
4	Subhendu S Bag Ishu Saraogi Jiantao Guo	Expansion of the Genetic Code: Unnatural Amino Acids and their Applications	Frontiers in Chemistry	2022
5	Anirban Das Yogesh Gangarde Ranit Pariary Anirban Bhunia Ishu Saraogi	An amphiphilic small molecule drives insulin aggregation inhibition and amyloid disintegration	International Journal of Biological Macromolecules	2022
6	Tulsi Upadhyay Vaibhav Karekar Upasana Potteth Ishu Saraogi	A buried interchain aromatic cluster in Escherichia coli GrpE governs in vivo thermosensing activity	Proteins	2022
7	Vaibhav Karekar Upasana Potteth Tulsi Upadhyay Ishu Saraogi	A stutter in the coiled-coil domain of E.coli co-chaperone GrpE connects structure with function	Biochemistry	2021
8	Jainu Ajit Anirban Das Yogesh Gangarde Ishu Saraogi	Synthesis and Evaluation of Arylamides with Hydrophobic Side Chains for Insulin Aggregation Inhibition	ChemPlusChem	2021
9	Anirban Das Tanoy Datta Laxmikant Gadhe Apurba Lal Koner Ishu Saraogi	Biocompatible fluorescent probe for selective detection of amyloid fibrils	Analytical Chemistry	2020
10	Anirban Das Yogesh Gangarde Viniti Tomar Omkar Shinde Tulsi Upadhyay Sarfaraz Alam Sudipta Ghosh Varun Chaudhary Ishu Saraogi	A small molecule inhibitor prevents insulin fibrillogenesis and preserves activity	Molecular Pharmaceutics	2020
11	Yogesh Gangarde Sajeev T K Nihar Panigrahi Ram K Mishra Ishu Saraogi	Amphiphilic small molecule assemblies to enhance the solubility and stability of hydrophobic drugs	ACS Omega	2020
12	Bapurao Bhoge Purnima Mala Jo S Kurian Varadharajan Srinivasan Ishu Saraogi	Selective functionalization at N2-position of guanine in oligonucleotides via reductive amination	Chemical Communications	2020
13	Vaibhav Karekar Bhoge Bapurao Saraogi Ishu	An expeditious synthetic route to proteomimetic foldamers	New Journal of Chemistry	2019
14	Ishu Saraogi Snehlata Saini Sudipta Ghosh	Peptide nucleic acid mediated inhibition of the bacterial signal recognition particle	Chemical Communications	2018
15	Ishu Saraogi David Akopian Shu-ou Shan	Real time fluorescence reveals the recognition, commitment, and unloading of cargo during co-translational protein targeting	Jl. Of Cell Biology	2014
16	Ishu Saraogi Shu-ou Shan	Co-translational protein targeting to the bacterial membrane	BBA-Molecular Cell Research	2014